COLLEGE FOOTBALL WEEK 4 · BETTING PREVIEW
Oregon vs. USC
USC’s defensive test is much different from Oregon’s tune-up
Kickoff:
Los Angeles Memorial Coliseum · Schedule
Public betting odds
| Team | Spread (price) | Moneyline |
|---|---|---|
| Oregon | -3 (-110) | -162 |
| USC | +3 (-110) | +136 |
Total: 62.5 · Over -108 / Under -112
Market update: Oregon moved from -2.5 to -3; the total held at 62.5.
DraftKings via ESPN · Checked September 24, 2026 at 3:16 PM ET. A source-specific snapshot, not a guaranteed live offer or a placed wager.
What carries into this matchup
Oregon
Oregon beat Portland State Vikings 84–0 on September 18, 2026. The offense finished with 726 total yards, 11-for-14 on third down, 0 turnovers. Dante Moore completed 19 of 23 passes for 280 yards, with 4 passing touchdowns and 0 interceptions. Box score · Scoring and play-by-play
USC
USC beat Rutgers Scarlet Knights 42–35 on September 19, 2026. The offense finished with 461 total yards, 5-for-10 on third down, 0 turnovers. Jayden Maiava completed 20 of 32 passes for 277 yards, with 2 passing touchdowns and 0 interceptions. Box score · Scoring and play-by-play
Matchup analysis
Oregon’s rout of Portland State demonstrates execution against an overmatched opponent, not proof its defense is ready for USC. The Trojans scored enough at Rutgers, but nearly equal yardage and a one-score finish show how little separation the defense created. An Oregon edge requires an opponent-adjusted argument, while USC needs more stops than it produced last week.
Availability and news to watch
Oregon receiver Jeremiah McClellan is out with a broken foot, while tight ends Jamari Johnson and Kendre Harrison are questionable. USC receiver Trent Mosley is doubtful. Oregon–USC Week 4 availability report
This preview will be updated as the week develops. Current odds are not a betting recommendation. Only wager what you can afford to lose.